Cell-derived microparticles in the pathogenesis of cardiovascular disease: friend or foe?

نویسندگان

  • Maarten E Tushuizen
  • Michaela Diamant
  • Augueste Sturk
  • Rienk Nieuwland
چکیده

Microparticles are ascribed important roles in coagulation, inflammation, and endothelial function. These processes are mandatory to safeguard the integrity of the organism, and their derangements contribute to the development of atherosclerosis and cardiovascular disease. More recently, the presumed solely harmful role of microparticles has been challenged because microparticles may also be involved in the maintenance and preservation of cellular homeostasis and in promoting defense mechanisms. Here, we summarize recent studies revealing these 2 faces of microparticles in cardiovascular disease.

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عنوان ژورنال:
  • Arteriosclerosis, thrombosis, and vascular biology

دوره 31 1  شماره 

صفحات  -

تاریخ انتشار 2011